Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 10 3 2018 08 30 114 123 ISAAC RAHIMIAN BOOGAR Department of Clinical Psychology, Faculty of Psychology and Educational Sciences, Semnan University, Semnan, Iran SIAVASH TALEPASAND Department of Educational Psychology, Faculty of Psychology and Educational Sciences, Semnan University, Semnan, Iran BEHNAM BARATI MASHHADI Department of Clinical Psychology, Faculty of Psychology and Educational Sciences, Semnan University, Semnan, Iran 2018 09 23 2019 05 25 The quality of nursing work life is an important index for assessing the professional health of nurses and providing tailored care services to patients. The study investigates the role of work-family conflict and self-regulation in predicting the quality of work-life among nurses. In this retrospective cross-sectional study, 230 nurses were selected randomly from public and private hospitals. They were asked to fill out Work-related Quality of Life Scale-2, Work-Family Conflict Scale, and Self-Regulation Questionnaire. Moreover, structural equation modeling was used to analyze the data by SPSS-19 and LISREL-8.80 software. The results showed that the model had a good fit to the observed data (RMSEA=0.06, GFI=0.93, AGFI=0.87, NFI=93, CFI=95, IFI=95, and P-value=.073) and the final model was verified. The results also revealed that “behavior-based and time-based work-family conflicts”, “assessing the plan’s effectiveness”, “searching for options”, and “implementing the plan” could significantly predict “stress at work”, “general well-being”, “working conditions”, employees’ engagement”, “job career satisfaction”, and “work-home interference” (p<0.05). It is indispensable to design tailored programs and professional health plans for improving family-work interference and self-regulatory actions, as two leading causes for the quality of nursing work life. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/368