Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 16 3 2025 08 30 35 44 Mohammad Khandan Department of Occupational Health and Safety Engineering, School of Health, Qom University of Medical Sciences, Qom, Iran; Department of Occupational Health and Safety Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Alireza Koohpaei Department of Occupational Health and Safety Engineering, School of Health, Qom University of Medical Sciences, Qom, Iran Seyed Abed Abedi Department of Occupational Health and Safety Engineering, School of Health, Qom University of Medical Sciences, Qom, Iran Mohammad Reza Azadeh Research Department, Qom Emergency Center, Qom, Iran Ali Montazeri Kara Amar Samin, Qom, Iran Ali Ebrahimi Department of Occupational Health and Safety Engineering, School of Health, Qom University of Medical Sciences, Qom, Iran 2024 11 03 2025 02 11 Background: Emergency medical personnel play a crucial role in saving the lives of patients and injured individuals before they receive hospital services. Given their working conditions and environment, emergency medical service personnel are at risk for mental health issues and musculoskeletal disorders. Therefore, this study aimed to investigate the relationship between stress, anxiety, and depression with musculoskeletal disorders among emergency medical personnel in Qom Province. Methods: This descriptive-analytical cross-sectional study was conducted among 177 emergency medical service personnel in Qom city, selected through simple random sampling. Data collection tools included demographic questionnaires, the Depression Anxiety Stress Scales (DASS), and a body map chart. Data analysis was performed using descriptive statistical tests and multivariate structural equation modeling techniques, as well as Cronbach’s alpha coefficients and average variance extracted (AVE) analysis, with the help of SPSS version 22 and AMOS version 20 software. Results: The average age of the participants was 33.03 ± 7.48 years. Most participants (84%) reported symptoms of musculoskeletal disorders. The reliability and validity of the DASS questionnaire and its subscales were confirmed with acceptable Cronbach’s alpha coefficients (0.7) and average variance extracted (AVE) values (0.4). Levels of stress, anxiety, and depression were above average. No significant relationship was found between stress, anxiety, and depression and musculoskeletal disorders, and demographic variables did not moderate the relationship between these psychological factors and musculoskeletal disorders. Conclusion: Given the high prevalence of musculoskeletal disorders and the elevated levels of stress, anxiety, and depression among emergency medical personnel—with no significant relationship found between these variables—it is essential to identify other influencing factors in this field. Implementing control measures to improve working conditions and the work environment is critical, especially considering the vital role of emergency medical personnel in the healthcare sector. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/653 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/653/840