Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 15 4 2025 08 30 57 66 EN Maryam Abbaszadeh Faculty of Rehabilitation, Department of Physiotherapy, Iran University of Medical Sciences, Tehran, Iran Mohammad Akbari Faculty of Health, Ergonomics Department, Iran University of Medical Sciences, Tehran, Iran Ehsan Garosi Faculty of Health, Ergonomics Department, Iran University of Medical Sciences, Tehran, Iran Farin Khanehshenas Faculty of Health, Ergonomics Department, Iran University of Medical Sciences, Tehran, Iran Mohammad Sadegh Ghasemi Faculty of Health, Ergonomics Department, Iran University of Medical Sciences, Tehran, Iran 2024 11 11 2025 02 04 Background: Due to demanding work hours and conditions, operating room technicians are at high risk of developing musculoskeletal disorders (MSDs). This study aimed to implement and evaluate the effectiveness of an ergonomic intervention program based on targeted exercise routines tailored to the needs of these professionals. Methods: This interventional study employed a before-and-after clinical trial design involving 40 operating room technicians (39 female, 1 male) at Rasool Akram Hospital. Data collection tools included the Nordic and Corlett questionnaires. Participants received training as part of a six-week ergonomic exercise program. Post-intervention data were analyzed using SPSS software. Results: Before the intervention, mean discomfort scores were high in the back (3.18), shoulder and arm (3.53), hand and wrist (0.48), and knee (2.07). Following the intervention, these values decreased to 2.37, 2.90, 0.30, and 1.68, respectively. Repeated measures ANOVA with Greenhouse-Geisser correction indicated statistically significant reductions in the back, neck, shoulder, arm (p < 0.001), and knee (p = 0.002). Conclusion: The findings demonstrate that an ergonomic exercise-based intervention can significantly reduce musculoskeletal discomfort among operating room technicians, highlighting the potential of such programs in occupational health strategies. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/655 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/655/858