Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 15 3 2025 08 30 29 48 Parisa Mohammad-Gholikhan-Khalaj Student Research Committee, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahdi Malakoutikhah Department of Occupational Health and Safety Engineering, Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran Hadiseh Rabiei School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Somayeh Farhang Dehghan Environmental and Occupational Hazards Control Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Occupational Health Engineering and Safety at Work, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2024 11 14 2025 05 03 The present meta-analysis aimed to compare the adsorption capacity of metal–organic frameworks for the removal of volatile organic compounds in the gas phase. Based on the results of the 66 studies included in the meta-analysis, it can be inferred that a significant amount of research has been conducted in this area. MOFs are widely used for VOC removal due to their large specific surface area, high pore volume, and strong thermal resistance. This 2022 systematic review and meta-analysis were conducted in accordance with the PRISMA checklist. Five electronic databases were searched for this review (Medline/PubMed, Embase, Scopus, ISI Web of Knowledge, and Google Scholar). The most frequently used MOF and VOC were NH₂-MIL-125 and toluene, respectively. The findings of the present study indicate that MOFs are among the emerging materials commonly used for the removal of volatile chemical substances. The adsorption capacity of MOFs for non-polar VOCs can be improved by enhancing their hydrophobicity and modifying their metal species and spatial configuration. In addition, the organic linkers in MOFs may exhibit favorable interactions with organic solvents. Therefore, MOFs can be considered promising materials for the adsorption and removal of VOC gases. Furthermore, adsorption capacity may be further improved by increasing the surface area. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/656 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/656/856