Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 17 2 2025 12 09 73 79 Zahrasadat Mousavifard Student Research Committee, Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Masoud Mohammadi Department of HSE Ahvaz Islamic Azad University, Ahavas, Iran Saber Moradi Hanifi Occupational Health Research Center, Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Shahram Vosoughi Occupational Health Research Center, Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran 2025 02 20 2025 05 11 Background: Rapid industrialization has led to a significant increase in work-related musculoskeletal disorders (WMSDs), driven by factors such as job demands, repetitive motions, workload intensity, and prolonged task durations. In the food industry, repetitive movements inherent to the work environment further elevate the risk of WMSDs. This study investigates the relationship between musculoskeletal disorders and occupational burnout among employees at the Bistoon Sugar Factory in Kermanshah. Methods: This descriptive survey included all 300 employees of the Bistoon Sugar Factory, selected through census sampling. Participants with pre-existing musculoskeletal conditions or injuries affecting the musculoskeletal system were excluded. Data were collected using the Nordic Musculoskeletal Questionnaire and the Maslach and Jackson Job Burnout Inventory. Reliability analysis using Cronbach’s alpha yielded coefficients of 0.948 for the burnout inventory and 0.757 for the Nordic questionnaire. Data were analyzed using SPSS version 22, employing Pearson’s correlation and regression analysis. Results: Significant positive correlations were found between musculoskeletal disorders (MSDs) and components of occupational burnout (p < 0.001). The strongest association was observed between MSDs and reduced personal accomplishment (β = 0.212–0.282). The modest R² values suggest that other unmeasured variables may also contribute to burnout. Conclusion: The high prevalence of musculoskeletal disorders (MSDs) negatively affects task performance and job satisfaction. Implementing ergonomic adjustments, targeted training programs, and organizational support systems can help mitigate these disorders and enhance workplace adaptability. Such interventions have the potential to improve both employee well-being and the overall quality of services. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/675 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/675/870