Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 17 3 2026 06 08 190 197 Siyavash Etemadinezhad Department of Occupational Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran Elahe Amouzadeh Department of Ergonomics, Hamadan University of Medical Sciences, Hamadan, Iran Jamshid Yazdani Charati Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 2025 08 11 2025 09 16 Background: Usability, as defined by ISO 9241-11, refers to the extent to which a system can be used effectively, efficiently, and with satisfaction in a specified context. Web-based academic research management platforms require high usability to ensure user satisfaction and productivity. This study aimed to evaluate the usability of the Integrated Research Automation System (Syat) at Mazandaran University of Medical Sciences. To the best of our knowledge, this study is among the first to systematically assess the usability of the Syat system in a medical academic setting. Methods: A cross-sectional, descriptive-analytical study was conducted among 130 faculty members who had used Syat at least five times for research-related activities. Six primary tasks were assessed: registering a thesis as a research project, granting and restricting student access to theses, submitting evaluations, editing thesis information, and overall system interaction. Effectiveness was measured by error rates, efficiency by task completion time, and satisfaction by the System Usability Scale (SUS). Statistical analysis included descriptive statistics, one-way ANOVA with Bonferroni post-hoc tests, and chi-square tests for associations between demographic factors and error rates. Results: The proportion of error-free performance ranged from 57.0% to 64.7%, with “Restrict Access” being the most error-prone (mean errors = 0.57). Task completion times varied significantly (F(5,1414) = 12.091, p < 0.001), with “Submit Evaluation” being the longest (mean = 79.80 s). SUS scores were low across all tasks (overall mean = 28.86), far below the benchmark of 68. Gender, education level, and work experience had a significant influence on error rates (p < 0.05). Conclusion: Although Syat allows task completion, low satisfaction and efficiency issues indicate the need for interface simplification, targeted training for less experienced users, and iterative user-centered design improvements. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/709 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/709/882