Tehran University of Medical Sciences International Journal of Occupational Hygiene 2008-5109 17 4 2026 09 13 217 226 Maryam Amirmahani Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mojtaba Kh . Danesh Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2025 11 28 2025 12 27 The advancement of digital technologies over the past three decades has led to a fundamental transformation in the fields of ergonomics and user-centered design. The RAMSIS software, as a pioneer in Digital Human Modeling (DHM), leverages extensive anthropometric data and advanced capabilities to enable precise analysis of human interaction with diverse work environments from vehicle interior to workstation design. This article, while reviewing the development history of RAMSIS, its main features, applications across various industries, and its limitations, outlines future research directions in this area. The results indicate that RAMSIS goes beyond being an industrial design tool and has evolved into a multidisciplinary platform for improving user health, safety, and comfort. https://ijoh.tums.ac.ir/index.php/ijoh/article/view/734 https://ijoh.tums.ac.ir/index.php/ijoh/article/download/734/888