Association of Depression and Body Mass Index with Inflammation Markers in Tehran Oil Refinery Shift Workers
Association of Depression with Inflammation Markers in Shift Workers
Abstract
Shift working with the sleep disturbance may lead to an increased body weight, depression levels, and inflammation. The purpose of this study was to determine the association between depression scores, Body Mass Index (BMI) and inflammation markers among rotational shift workers in one of the Iranian Oil Refineries. A cross-sectional study was conducted among 189 shift workers aged 21-52 years old with mean 30.58(±6.970) in one of the oil refineries in Tehran city. Studied population was in an 8 hours backward shift (from night to morning). Demographic characteristics were gathered by a general questionnaire and anthropometric variables including weight and height were measured for calculating body mass index (BMI), were calculated. 21-items Beck Depression Inventory, which was translated in Persian, was used to assess the depressive symptoms. Level of Cortisol, IL-6 and hs-CRP was measured by 8 ml fasting blood sample, using RIA kit in radioimmunoassay method, R&D (Germany) kit in enzyme-linked immunosorbent method and quantitative diagnostic kit in immunoturbidimetry method produced by Pars Azmoon Company, respectively. The results of the current study showed that Il-6 and hs-CRP were higher, in workers with depression scores more than 9 in comparison with workers by depression scores equal or below 9 measured by the 21- Item Beck depression inventory. Although there were not statistically significant. There was inverse association between cortisol level and BMI (P-Value<0.01) and positive association between CRP and BMI (PV<0.01) and borderline positive association between IL-6 concentration with BMI (P-Value<0.05). The results of the study revealed that there was a direct association between inflammation factors with Body Mass Index in Tehran oil refinery shift workers. But, the significant relationship between cortisol level, IL-6 and CRP with Shift Work experience were not found.
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14. Giovanni Amodeo , Maria Allegra Trusso, Andrea Fagiolini. Depression and Inflammation: Disentangling a Clear Yet Complex and Multifaceted Link. Neuropsychiatry (London) 2017. 7(4): p. 448-457.
15. Christopher J. Morris1, T.E.P., Joseph Mistretta., Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J. Biol. Rhythms, 2017. 32(2): p. 154-164.
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24. Calabro P, C.D., Willerson JT, Yeh ET., Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. JACC CardioOncol, 2005. 46: p. 1112-1113.
25. Khajehnasiri F, A.S., Mortazavi SB, et al., Oxidative Stress and Depression among Male Shift Workers in Shahid Tondgouyan Refinery. Iran J Psychiatry, 2014. 9(2): p. 76-82.
26. Choobineh A, S.A., Tabatabaee H, et al., Shift work related psychosocial problems in 12-hour shift schedules of petrochemical industries. IJHOH, 2011. 3(1): p. 38-42.
27. Khosro, S., Alireza, S, Omid, A, Forough,S., Night work and inflammatory markers. Indian J Occup Environ Med, 2011. 15(1): p. 38-41.
28. Lieu, S., Curhan, GC, Schernhammer, ES, Forman, JP., Rotating night shift work and disparate hypertension risk in African-Americans. J Hypertens, 2012. 30(1): p. 61-66.
29. Chieh-Hsin Lee, F.G., The Role of Inflammation in Depression and Fatigue. Front Immunol, 2019. 10: p. 1696.
30. Giovanni Amodeo, M.A.T.a.A.F., Depression and Inflammation: Disentangling a Clear yet Complex and Multifaceted Link. Neuropsychiatry (London), 2017. 7(4): p. 448-457.
31. Miller., C.L.R.a.A.H., Is Depression an Inflammatory Disorder? Curr Psychiatry Rep, 2011. 13(6): p. 467-475.
32. Pasco, J.A., et al., Association of high-sensitivity C-reactive protein with de novo major depression. BRIT J PSYCHIAT, 2010. 197(5): p. 372-377.
33. Ford, D.E. and T.P. Erlinger, Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med., 2004. 164(9): p. 1010-1014.
34. Howren, M.B., D.M. Lamkin, and J. Suls, Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic medicine, 2009. 71(2): p. 171-186.
35. Park, H.S., J.Y. Park, and R. Yu, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res Clin Pract Suppl, 2005. 69(1): p. 29-35.
36. Yamamoto, K., A. Okazaki, and S. Ohmori, The relationship between psychosocial stress, age, BMI, CRP, lifestyle, and the metabolic syndrome in apparently healthy subjects. J Physiol Anthropol, 2011. 30(1): p. 15-22.
37. Choi, J., L. Joseph, and L. Pilote, Obesity and C‐reactive protein in various populations: a systematic review and meta‐analysis. Obes Rev, 2013. 14(3): p. 232-244.
38. Travison, T.G., et al., Cortisol levels and measures of body composition in middle‐aged and older men. Clin. Endocrinol., 2007. 67(1): p. 71-77.
39. Champaneri, S., et al., Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis. Obesity, 2013. 21(1): p. E56-E63.
40. Schorr, M., et al., Cortisol measures across the weight spectrum. J. Clin. Endocrinol. Metab., 2015. 100(9): p. 3313-3321.
2. Wang XS, A.M., Cairns BJ, et al, Shift work and chronic disease: the epidemiological evidence. Occup Med (Lond), 2011. 61: p. 78-89.
3. Wong IS, M.C., Demers PA, Shift work trends and risk of work injury among Canadian workers. Scand J Work Environ Health, 2011. 37(1): p. 54-61.
4. King RN, M.C., Koehoom M, Sleep problems and workplace injuries in Canada. Sleep, 2010. 33(5): p. 611-618.
5. Garbarino S, De Carli F, Nobili L, Mascialino B, Squarcia S, Penco MA, Beelke M, Ferrilla F. Sleepiness and sleep disorders in shift workers: a study on a group of italian police officers. Sleep. 2002 Sep 15;25(6):648-53. PMID: 12224843.
6. Edell-Gustafsson UM, K.E., Bogren IK, Self-reported sleep quality, strain and health in relation to perceived working conditins in females. Scand J Caring Sci, 2002. 16(2): p. 179-187.
7. Lamod N, D.J., Roach K, et al, The impact of a week of simulated night work on sleep, circadian phase, and performance. J. Occup. Environ. Med, 2003. 60(11): p. e13.
8. Ingrid Philibert. Sleep loss and performance in residents and nonphysicians: a meta analytic examinatin. Sleep, 2005. 28(11): p. 1392-1402.
9. DeVargas V, V.D.A., Depression prevalence in Intensive Care Unit nursing workers: a study at hospitals in a northwestern city of São Paulo State Rev. Latino-Am, 2011. 19(5): p. 1114-1121.
10. Bruce S, McEwen., Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load Metabolism, 2006. 55(suppl): p. S20-S23.
11. Sookoian S, G.C., Fernandez Gianotti T, Burgueno A, Alvarez A, Gonzalez CD, Pirola CJ., Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation. Journal of internal medicine, 2007. 261(3): p. 285-292.
12. Krishnadas R, C.J., Depression: an inflammatory illness? J. Neurol. Neurosurg. Psychiatry 2012. 83(5): p. 495-502.
13. Meier-Ewert HK, R.P., Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM, Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology, 2004. 43(4): p. 678-683.
14. Giovanni Amodeo , Maria Allegra Trusso, Andrea Fagiolini. Depression and Inflammation: Disentangling a Clear Yet Complex and Multifaceted Link. Neuropsychiatry (London) 2017. 7(4): p. 448-457.
15. Christopher J. Morris1, T.E.P., Joseph Mistretta., Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J. Biol. Rhythms, 2017. 32(2): p. 154-164.
16. Morris, C., Purvis, TE, Mistretta, J, Scheer, FA, Effects of the internal circadian system and circadian misalignment on glucose tolerance in chronic shift workers. J.Clin.Endocrinol.Metab, 2016. 101(3): p. 1066-1074.
17. Wright, K., Drake, AL, Frey, DJ, Fleshner, M, Desouza, CA, Gronfier, C, Czeisler, CA., Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain.Behav.Immun, 2015. 47: p. 24-34.
18. Mårin P, D.N., Amemiya T, Andersson B, Jern S, Björntorp P., Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism, 1992. 41: p. 882-886.
19. Yudkin JS, S.C., Emeis JJ, Coppack S. W. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis, Thrombosis & Vascular Biology. Arterioscler. Thromb. Vasc. Biol., 1999. 19(4): p. 972-978.
20. Dandona P, W.R., Thusu K, Abdel-Rahman E, Aljada A, Wadden T., Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J. Clin. Endocrinol. Metab., 1998. 83(8): p. 2907-2910.
21. Bochud M, M.F., Marques-Vidal PM, Vollenweider P, Beckmann JS, Mooser V, Paccaud F, Rousson V., Association between C-reactive protein and adiposity in women. J Endocrinol Metab, 2009. 94(10): p. 3969-3977.
22. Schmidt MI, D.B., Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, Azambuja MI, Tracy RP, Heiss G., Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet.Oncol., 1999. 15(353): p. 1649-1652.
23. Greenfield JR, S.K., Jenkins AB, Kelly PJ, Spector TD, Gallimore JR, Pepys MB, Campbell LV., Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences. Circulation, 2004. 109(24): p. 3022-3028.
24. Calabro P, C.D., Willerson JT, Yeh ET., Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. JACC CardioOncol, 2005. 46: p. 1112-1113.
25. Khajehnasiri F, A.S., Mortazavi SB, et al., Oxidative Stress and Depression among Male Shift Workers in Shahid Tondgouyan Refinery. Iran J Psychiatry, 2014. 9(2): p. 76-82.
26. Choobineh A, S.A., Tabatabaee H, et al., Shift work related psychosocial problems in 12-hour shift schedules of petrochemical industries. IJHOH, 2011. 3(1): p. 38-42.
27. Khosro, S., Alireza, S, Omid, A, Forough,S., Night work and inflammatory markers. Indian J Occup Environ Med, 2011. 15(1): p. 38-41.
28. Lieu, S., Curhan, GC, Schernhammer, ES, Forman, JP., Rotating night shift work and disparate hypertension risk in African-Americans. J Hypertens, 2012. 30(1): p. 61-66.
29. Chieh-Hsin Lee, F.G., The Role of Inflammation in Depression and Fatigue. Front Immunol, 2019. 10: p. 1696.
30. Giovanni Amodeo, M.A.T.a.A.F., Depression and Inflammation: Disentangling a Clear yet Complex and Multifaceted Link. Neuropsychiatry (London), 2017. 7(4): p. 448-457.
31. Miller., C.L.R.a.A.H., Is Depression an Inflammatory Disorder? Curr Psychiatry Rep, 2011. 13(6): p. 467-475.
32. Pasco, J.A., et al., Association of high-sensitivity C-reactive protein with de novo major depression. BRIT J PSYCHIAT, 2010. 197(5): p. 372-377.
33. Ford, D.E. and T.P. Erlinger, Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med., 2004. 164(9): p. 1010-1014.
34. Howren, M.B., D.M. Lamkin, and J. Suls, Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic medicine, 2009. 71(2): p. 171-186.
35. Park, H.S., J.Y. Park, and R. Yu, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res Clin Pract Suppl, 2005. 69(1): p. 29-35.
36. Yamamoto, K., A. Okazaki, and S. Ohmori, The relationship between psychosocial stress, age, BMI, CRP, lifestyle, and the metabolic syndrome in apparently healthy subjects. J Physiol Anthropol, 2011. 30(1): p. 15-22.
37. Choi, J., L. Joseph, and L. Pilote, Obesity and C‐reactive protein in various populations: a systematic review and meta‐analysis. Obes Rev, 2013. 14(3): p. 232-244.
38. Travison, T.G., et al., Cortisol levels and measures of body composition in middle‐aged and older men. Clin. Endocrinol., 2007. 67(1): p. 71-77.
39. Champaneri, S., et al., Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis. Obesity, 2013. 21(1): p. E56-E63.
40. Schorr, M., et al., Cortisol measures across the weight spectrum. J. Clin. Endocrinol. Metab., 2015. 100(9): p. 3313-3321.
| Files | ||
| Issue | Vol 12 No 4 (2020) | |
| Section | Original Article(s) | |
| Published | 2020-12-16 | |
| Keywords | ||
| Depression BMI Shift work Oil refinery Inflammation | ||
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How to Cite
1.
Khajehnasiri F, Mortazavi SB, Zaroushani V. Association of Depression and Body Mass Index with Inflammation Markers in Tehran Oil Refinery Shift Workers. Int J Occup Hyg. 2020;12(4):327-333.
