Original Article

Measurement of Urinary Cadmium in Glazers Using Solid Phase Extraction Followed by Inductively Coupled Plasma Atomic Emission Spectroscopy


Glazers are exposed to a variety of heavy metals in the ceramic industry, causing adverse effect on the body systems. Cadmium is one of the major raw materials for production of colored glazes. To evaluate occupational exposure to cadmium, spot urine samples were collected from 49 tile and pottery glazers n Yazd City in 2010 at the beginning and end of the work shift (98 samples). Totally, 55 office workers  ere also evaluated as control group. Samples were prepared using solid phase extraction followed by  nductively Coupled Plasma Atomic Emission Spectroscopy. All the participants filled out a self administered questionnaire comprises questions about work shift, kind of job, use of mask, ventilation, work history, overtime work, age, weight, and height. The lung function tests were performed in a standing position according to the American Thoracic Society recommendation on both control and cadmium exposed individuals. Analysis of covariance (ANCOVA) was used to evaluate the data. The mean values of cadmium levels before and after shift in study group was 3.88 and 10.85 μg/gcreatinine, respectively. The mean values of cadmium levels at the end of the work shift in the glazers urine  amples was almost 3.53 times higher than the control group and 2.17 times higher than the ACGIH biological exposure indices (5 μg/g creatinine). In addition the lung functions of glazers was significantly lower than the office workers (p<0.001). Exposure to cadmium in ceramic industry can lead to the reduction of respiratory capacity. Hygienic behaviors such as using protective mask and working in efficient  entilated workplaces can decrease the rate of occupational exposure to cadmium.

Robin PH. Cadmium risk assessment of an exposed residential population: J R Soc Med 1985; 78(4): 328-333.

Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A, Groneberg D. The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol 2006; 1(22): 1-6.

Cepria G, Garcia-Gareta E, Perez-Arantegui J. Cadmium yellow detection and quantification by voltammetry of immobilized microparticles. Electroanalysis 2005; 17(12): 1078-1084.

Holburn GW. New technologies: current and future implications for health and safety. Ann Occup Hyg 1989; 33( 3): 459-463.

Leman RL. Lead glazes for ceramic foodware. 1st ed, The International Lead Management Center, USA, 2002.

Beton DC, Andrews GS, Davies HJ, Leonard H, Smith GF.Acute cadmium fumes poisoning: five cases with one death from renal necrosis. Br J Ind Med 1966; 23(4): 292-301.

Adams RG, Harrison JF, Scott P. The development of cadmiuminduced proteinuria, impaired renal function, and osteomalacia in alkaline battery workers. Q J Med 1969; 38(4): 425-443.

Kazantzis G. Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers. Environ Health Perspect 1979; 28: 155-159.

Mason HJ, Davison AG, Wright AL, Guthrie CJ, Fayers PM. Relations between liver, cadmium, cumulative exposure, and renal function incadmium alloy workers. Br J Ind Med 1988; 45(12): 793-802.

Leman RA, Lee JS, Wagoner JK, Blejer HP. Cancer mortality among cadmium production workers. Ann N Y Acad Sci 1976; 271: 273-279.

Kjellstrom T, Friberg L, Rahnstert B. Mortality and cancer morbidity among cadmium-exposed orkers. Environ Health Perspect 1979; 28: 199-204.

Bako G, Smith ESO, Hanson J, Dewar R. The geographical distribution of high cadmium concentrations in the environment and prostate cancer in Alberta. Can J Public Health 1982; 73(2): 92-94.

Elinder CG, Kjellstrom T, Hogstedt C, Andersson K, Spang G.Cancer mortality of cadmium workers. Br J Ind Med 1985; 42(10): 651-655.

Sorahan T. Mortality from lung cancer among a cohort of nickel cadmium battery workers: 1946-1984. Br J Ind Med 1987; 44(12): 803-809.

Ades AE, Kazantzis G. Lung cancer in a non-ferrous smelter: the role of cadmium. Br J Ind Med 1988; 45(70: 435-442.

Sorahan T, lister A, Gilthorpe MS. Mortality of copper cadmium alloy workers with special reference to lung cancer and nonmalignant diseases of the respiratory system 1946-92. Occup Environ Med 1995; 52(12): 804-812.

Shahtaheri SJ, Khadem M, Golbabaei F, Rahimi-Froushani A. Optimization of sample preparation procedure for evaluation of occupational and environmental exposure to Nickel. Iranian J Public Health 2007; 36 (2):73-81.

Shahtaheri SJ, Khadem M, Golbabaei F, Rahimi-Froushani A. Solid phase extraction for evaluation of occupational exposure to Pb (II) using XAD-4 prior to atomic absorption spectroscopy. Int J Occup Saf Ergon 2007; 13 (2): 137-145.

Shahtaheri SJ, Mesdaghinia A. Stevenson D. Evaluation of factors influencing recovery of herbicide 2,4-D from drinking water. Iranian J Chem & Chem Engin 2005; 24(1): 33-40.

Shahtaheri SJ, Ibrahimi L, Golbabaei F, Hosseini M. Solid phase extraction for 1-hydroxypyrene as a biomarker of exposure to PAHs prior to high performance liquid chromatography. Iranian J Chem & Chem Engin 2007; 26(4): 75-81.

Shahtaheri SJ, Abdollahi M, Golbabaei F, Rahimi-Froushani A, Ghamari F. Sample preparation followed by HPLC for monitoring of mandelic acid as a biomarker of environmental and occupational exposures to styrene. Int J Environ Res 2008; 2(2):169-176.

Koohpaei AR, Shahtaheri SJ, Ganjali MR, Rahimi-Froushani A, Golbabaei F. Molecular imprinted solid phase extraction for determination of atrazine in environmental samples. Iranian J Environ Health Sci Engin 2008; 5(4):283-296.

Heidari HR, Shahtaheri SJ, Golbabaei F, Alimohamadi M, Rahimi-Froushani A. Trace analysis of xylene in occupational exposures monitoring. Iranian J Publ Health 2009; 38(1): 89- 99.

Rahiminejad M, Shahtaheri SJ, Ganjali MR, Rahimi-Froushani, Koohpaei AR A, Golbabaei F. An experimental investigation of the molecularly imprinted polymers as tailor-made sorbents of diazinon. J Analyt Chem 2010; 65(7): 694-698.

American Conference of Governmental Industrial Hygienists. threshold limit values for chemical substances and physical agents and biological exposure indices, Cincinnati, ACGIH, 2010.

Vahter M, Allen Counter S, Laurell G, Buchanan LH, Ortega F, Schütz A, Skerfving S. Extensive lead exposure in children living in an area with production of lead-glazed tiles in the Ecuadorian Andes. Int Arch Occup Environ Health 1997; 70(4): 282–286.

Bache CA, Lisk DJ, Scarlett JM, Carbone LG. Epidemiologic study of cadmium and lead in the hair of ceramists and dental personnel. J Toxicol Environ Health 1991; 34(4): 423 – 431.

Telisman S, Azaric J, Prpic-Majic D. Cadmium in blood as an indicator of integrated exposure to cadmium in the urban population. Bull Environ Contam Toxicol 1986; 36(1): 491-495.

Berglund M, Lind B, Lannero E, Vahter M. A pilot study of lead and cadmium exposure in young children in Stockholm, Sweden: methodological considerations using capillary blood microsampling. Arch Environ Contam Toxicol 1994; 27(2): 281– 287.

Huzior-Balajewicz A, Pietrzyk JJ, Schlegel-Zawadzka M, Piatkows-ka E, Zachwieja Z. The influence of lead and cadmium environmental pollution on anthropometric health factors in children. Przegl Lek 2001; 58(4): 315–324.

Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Skerfving A. Cadmium in blood and urine—impact of sex, age, dietary intake, iron status, and former smoking—association of renal effects; Environ Health Perspectives 2002; 110(12): 1185- 1190.

Nordberg M, Winblad B, Basun H. Cadmium concentration in blood in an elderly urban population. BioMetals 2000; 13(4): 311–317.

Halvani Gh, Zarei M, Halvani2 A, Barkhordari A. Evaluation and comparison of respiratory symptoms and lung capacities in tile and ceramic factory workers of Yazd. Arch Ind Hyg Occup Med 2008; 59(3): 197-204.

Bahrami AR, Mahjub H. Comparative study of lung function in Iranian factory workers exposed to silica dust. East Mediterr Hlth J 2003; 9(3): 390- 8.

Dehghan F, Mohammadi S, Sadeghi Z, Attarchi M. Respiratory complaints and spirometric parameters in tile and ceramic factory workers. Tanaffos 2009; 8(4): 19-25.

Lauwerys RR, Buchet JP, Roels HA, Brouwers J, Stanescu D. Epidemiological survey of workers exposed to cadmium. Effect on lung, kidney, and several biological indices. Arch Environ Health 1974; 28(3): 145–8.

Jakubowki M, Abramowska-Guzik A, Szymczak W , Trzcinka Ochockam M. Influece of long-term occupational exposure to cadmium on lung function tests results. Int J Occup Med Environ Health 2004; 17(3): 361 – 368.

Sheets RW. Release of heavy metals from European and Asian porcelain dinnerware. Sci Total Environ 1998; 212(2-3): 107- 113.

Sheets RW. Acid extraction of lead and cadmium from newly purchased ceramic and melamine dinnerware. Sci Total Environ 1999; 234(1-3): 233-7.

IssueVol 4 No 2 (2012) QRcode
SectionOriginal Article(s)
Urine cadmium Ceramic industry Glaze ICP-AES Spirometry

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How to Cite
KARGAR F, SHAHTAHERI SJ, GOLBABAEI F, BARKHORDARI A, RAHIMI–FROUSHANI A. Measurement of Urinary Cadmium in Glazers Using Solid Phase Extraction Followed by Inductively Coupled Plasma Atomic Emission Spectroscopy. Int J Occup Hyg. 2015;4(2):11-16.