Original Article

Application of Solid Phase Microextraction followed by Chromatograph-Flame Ionization Detector for Sampling and Analysis of Acetonitrile in Air


Acetonitrile used as a solvent in manufactures and affects to central nervous system from inhalation exposure. The aim of this study was to develop a micro-solid phase extraction method for  the determination of acetonitrile in the air matrix. The sampling was performed with a small diameter fused silica fiber coated with a thin film of stationary phase and was subsequently desorbed and analyzed by gas chromatograph equipped with a flame ionization detector (GC/FID). The effects of laboratory and sampling parameters were investigated and applied to the determination of acetonitrile in air matrix. The Carboxen/PDMS  as the coating fiber showed better analytical performances compared to the PDMS fiber. Analysis of the data by ANOVA test at a 0.05 level of accuracy showed that the peak area of the sampler was significantly affected by temperature and humidity so that the optimum temperature was 20°C and the optimum humidity was 35%. Besides, the limit of detection (LOD) and limit of quantification (LOQ) for acetonitrile in the GC system were 0.05 and 0.15 μg/ml, respectively. The solid phase  microextraction (SPME) has been shown a suitable technique for sampling and analysis of acetonitrile in air. There was a good correlation between the SPME and national institute occupational safety and health (NIOSH) 1010 method under the optimum conditions.

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IssueVol 5 No 4 (2013) QRcode
SectionOriginal Article(s)
Acetonitrile Solid Phase Micro Extraction Gas Chromatography

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How to Cite
KURD N, BAHRAMI A, GHORBANI-SHAHNA F, HEIDARI M. Application of Solid Phase Microextraction followed by Chromatograph-Flame Ionization Detector for Sampling and Analysis of Acetonitrile in Air. Int J Occup Hyg. 2015;5(4):177-183.