Development and Prevention of Noise-induced Hearing Loss: The Role of Oxidative Stress and Antioxidants
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Abstract
Exposure to industrial, military, and other occupational noises can cause noise-induced hearing loss (NIHL), which poses significant health risks for workers but is also potentially preventable. Currently, there is no effective treatment for NIHL, as mammalian cochlear hair cells cannot regenerate once damaged. Therefore, preventing hair cell death or implementing early therapeutic intervention is essential for preserving hearing function. NIHL is a complex condition that results from multiple pathophysiological changes. Recent studies on cochlear cellular structures have revealed promising strategies for NIHL prevention through the development of protective pharmacological agents. Reduced cochlear blood flow, inflammation, and oxidative stress are recognized as key mechanisms contributing to NIHL, with oxidative stress playing a particularly critical role. This research aimed to investigate the link between oxidative stress and the onset of NIHL, as well as to explore the potential of endogenous and exogenous antioxidant defense mechanisms in its prevention.
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7. Neitzel RL, Fligor BJ. Risk of noise-induced hearing loss due to recreational sound: review and recommendations. J Acoust Soc Am. 2019;146(5):3911.
8. Fetoni AR, Eramo SLM, Paciello F, Rolesi R, Troiani D, Paludetti G. Role of antioxidant supplementation in preventing noise-induced hearing loss. Hear Balance Commun. 2015;13(4):160–5.
9. Fetoni AR, Paciello F, Rolesi R, Paludetti G, Troiani D. Targeting dysregulation of redox homeostasis in noise-induced hearing loss: oxidative stress and ROS signaling. Free Radic Biol Med. 2019;135:46–59.
10. Zhou J, Shi Z, Zhou L, Hu Y, Zhang M. Occupational noise-induced hearing loss in China: a systematic review and meta-analysis. BMJ Open. 2020;10(9):e039576.
11. Mousavi SM, Abbasi M, Yazdanirad S, Yazdanirad M, Khatooni E. Fuzzy AHP-TOPSIS method as a technique for prioritizing noise control solutions. Noise Control Eng J. 2019;67(6):415–21.
12. Etemadinezhad S, Sammak Amani A, Moosazadeh M, Rahimlou M, Samaei SE. Occupational noise-induced hearing loss in Iran: a systematic review and meta-analysis. Iran J Public Health. 2023;52(2):278–89.
13. Chen KH, Su SB, Chen KT. An overview of occupational noise-induced hearing loss among workers: epidemiology, pathogenesis, and preventive measures. Environ Health Prev Med. 2020;25(1):65.
14. Rosati R, Jamesdaniel S. Environmental exposures and hearing loss. Int J Environ Res Public Health. 2020;17(13):4875.
15. Sundar PS, Chowdhury C, Kamarthi S. Evaluation of human ear anatomy and functionality by axiomatic design. Biomimetics (Basel). 2021;6(2):34.
16. Ni G, Elliott SJ, Ayat M, Teal PD. Modelling cochlear mechanics. Biomed Res Int. 2014;2014:150637.
17. Elliott SJ, Ni G. An elemental approach to modelling the mechanics of the cochlea. Hear Res. 2018;360:14–24.
18. Pickles J. An introduction to the physiology of hearing. Leiden: Brill; 2012.
19. Zhang LW, Cang XH, Chen Y, Guan MX. In vitro culture of mammalian inner ear hair cells. J Zhejiang Univ Sci B. 2019;20(2):170–9.
20. White HJ, Helwany M, Biknevicius AR, Peterson DC. Anatomy, head and neck, ear organ of Corti. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
21. Ceylan SM, Uysal E, Altinay S, Sezgin E, Bilal N, Petekkaya E, et al. Protective and therapeutic effects of milrinone on acoustic trauma in rat cochlea. Eur Arch Otorhinolaryngol. 2019;276(7):1921–31.
22. Ji L, Lee HJ, Wan G, Wang GP, Zhang L, Sajjakulnukit P, et al. Auditory metabolomics, an approach to identify acute molecular effects of noise trauma. Sci Rep. 2019;9(1):9273.
23. Gedik Ö, Doğan R, Babademez MA, Karataş E, Aydın M, Koçyiğit A, et al. Therapeutic effects of metformin for noise induced hearing loss. Am J Otolaryngol. 2020;41(1):102328.
24. Ding T, Yan A, Liu K. What is noise-induced hearing loss? Br J Hosp Med (Lond). 2019;80(9):525–9.
25. Alvarado JC, Fuentes-Santamaría V, Melgar-Rojas P, Gabaldón-Ull MC, Cabanes-Sanchis JJ, Juiz JM. Oral antioxidant vitamins and magnesium limit noise-induced hearing loss by promoting sensory hair cell survival: role of antioxidant enzymes and apoptosis genes. Antioxidants (Basel). 2020;9(12):1301.
26. Zhao RZ, Jiang S, Zhang L, Yu ZB. Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med. 2019;44(1):3–15.
27. Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, et al. Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice. Neurosci Lett. 2017;642:123–8.
28. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev. 2017;2017:8416763.
29. Zhao H, Zhang R, Yan X, Fan K. Superoxide dismutase nanozymes: an emerging star for anti-oxidation. J Mater Chem B. 2021;9(35):6939–57.
30. Zhang Y, Neng L, Sharma K, Hou Z, Johnson A, Song J, et al. Pericytes control vascular stability and auditory spiral ganglion neuron survival. Elife. 2023;12:e83486.
31. Talaska AE, Schacht J. Mechanisms of noise damage to the cochlea. Audiol Med. 2007;5(1):3–9.
32. Le Prell CG, Yamashita D, Minami SB, Yamasoba T, Miller JM. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res. 2007;226(1–2):22–43.
33. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006;27(1):1–19.
34. Mao H, Chen Y. Noise-induced hearing loss: updates on molecular targets and potential interventions. Neural Plast. 2021;2021:4784385.
35. Armada-Moreira A, Gomes JI, Pina CC, Savchak OK, Gonçalves-Ribeiro J, Rei N, et al. Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases. Front Cell Neurosci. 2020;14:90.
36. Demirel R, Mollaoğlu H, Yeşilyurt H, Üçok K, Ayçiçek A, Akkaya M, et al. Noise induces oxidative stress in rat. Eur J Gen Med. 2009;6(1):20–4.
37. Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC. Cellular mechanisms of noise-induced hearing loss. Hear Res. 2017;349:129–37.
38. Li R, Jia Z, Trush MA. Defining ROS in biology and medicine. Reactive Oxygen Species (Apex). 2016;1(1):9–21.
39. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30(1):11–26.
40. Tavanai E, Mohammadkhani G. Role of antioxidants in prevention of age-related hearing loss: a review of literature. Eur Arch Otorhinolaryngol. 2017;274(4):1821–34.
41. Sharifi-Rad M, Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020;11:694.
42. Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D, et al. Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. 2019;2019:5080843.
43. Devasagayam TP, Boloor KK, Ramasarma T. Methods for estimating lipid peroxidation: an analysis of merits and demerits. Indian J Biochem Biophys. 2003;40(5):300–8.
44. Chatterjee N, Walker GC. Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen. 2017;58(5):235–63.
45. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19.
46. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15(1):71.
47. Rosa AC, Corsi D, Cavi N, Bruni N, Dosio F. Superoxide dismutase administration: a review of proposed human uses. Molecules. 2021;26(7):1844.
48. McFadden SL, Ohlemiller KK, Ding D, Shero M, Salvi RJ. The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice. Noise Health. 2001;3(11):49–64.
49. Curhan SG, Stankovic KM, Eavey RD, Wang M, Stampfer MJ, Curhan GC. Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr. 2015;102(5):1167–75.
50. Doosti A, Lotfi Y, Moossavi A, Bakhshi E, Talasaz AH, Hoorzad A. Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise-induced hearing loss in male textile workers. Noise Health. 2014;16(71):223–7.
51. Gok U, Halifeoglu I, Canatan H, Yildiz M, Gursu MF, Gur B. Comparative analysis of serum homocysteine, folic acid and vitamin B12 levels in patients with noise-induced hearing loss. Auris Nasus Larynx. 2004;31(1):19–22.
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| Files | ||
| Issue | Vol 15 No 3 (2023) | |
| Section | Original Article(s) | |
| Published | 2025-08-30 | |
| Keywords | ||
| Noise, Noise-induced hearing loss, Oxidative Stress, Antioxidants | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Rezaei-Hachesu V, Naderyan Fe’li S, Hokmabadi R. Development and Prevention of Noise-induced Hearing Loss: The Role of Oxidative Stress and Antioxidants. Int J Occup Hyg. 2025;15(3):36-43.
